Hypothyroidism

What is Hypothyroidism?

The thyroid gland is a butterfly shaped gland situated just below your adam’s apple in the neck.  Its produces the thyroid hormones, triiodothyronine (T3) and thyroxine (T4).  The thyroid gland produces more T4 but T3 is the most potent hormone.  T3 is also generated by conversion of T4 after secretion from the thyroid gland.  These two hormones are important in metabolism and the metabolic rate.  Excess thyroid hormone results in a high metabolic rate increased heartrate and weight loss whereas deficient thyroid hormone results in a low metabolic rate, low body temperature, slow pulse and weight gain.

What causes Hypothyroidism?

Hypothyroidism can be a result of dysfunction of the thyroid gland (primary hypothyroidism) or less commonly a result of failure of the pituitary (secondary hypopituitarism), which stimulates the thyroid through the hormone TSH (Thyroid Stimulating Hormone). The most common cause of primary hypothyroidism is autoimmune destruction of the thyroid gland.  This is where the body’s own immune system attacks the thyroid gland and prevents it producing thyroid hormone.  Less commonly the thyroid maybe removed surgically because of thyroid lumps or tumours resulting in long term hypothyroidism.  Secondary hypothyroidism during pituitary disease is most commonly caused by a benign pituitary tumour or surgery for the tumour.  Rarely, hypothyroidism can be congenital (inherited) and this can be both primary and secondary.

How common is Hypothyroidism?

Hypothyroidism can occur at any age but is more frequent in the elderly and it is estimated that up to 5% of people over 60 years are hypothyroid.

What are the symptoms of Hypothyroidism?

The signs and symptoms of hypothyroidism are relatively nonspecific but include: tiredness, weight gain, cold intolerance, constipation, joint and muscle pain, dry skin, thin and brittle hair or fingernails.  In younger patients it may be a cause of infertility.

What is the current treatment?

The majority of patients are currently treated with thyroxine (T4) tablets.  These are taken on a daily basis.  However some patients may take T3 with T4 or T3 alone.

What are the limitations of current treatment for Hypothyroidism?

Despite conventional thyroxine replacement being widely available more than 25% of patients with Hypothyroidism report that they have an impaired quality of life.  It has been suggested that this may relate to lack of T3 however currently there are no formulations of the T3 that provide physiological replacement as the T3 is rapidly cleared from the circulation.

What is the Diurnal approach to treating Hypothyroidism?

Diurnal has completed an initial formulation development to enable a selection of a suitable technology to generate new formulations of T4 and T3 which will allow the replacement of the normal physiological ratio of T4 to T3.   It is anticipated that this will address the unmet need of the 25% of patients who have a poor quality of life on current therapy.

Further support for people affected by Hypothyroidism

BTF LogoThe British Thyroid Foundation works closely with patients and medical professionals to produce reliable information and practical support for people affected by all thyroid disorders.

Visit the British Thyroid Foundation website for further information.